Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. Pain, swelling, or redness at the injection site may occur. These lists contain examples of serious side effects that can occur with Injectafer, with Feraheme, or with both drugs (when taken individually). This gives a total cumulative dose of 1,500 mg of Injectafer. What are the side effects of Venofer? With IDA, you have anemia (low red blood cell level) thats due to not having enough iron in your body. But for other people, doing so could lead to having too much iron in their body. Injectafer contains the active drug ferric carboxymaltose. The drug helps increase your hemoglobin level back to a value thats within the normal range. Call your doctor for medical advice about side effects. fever, cold or flu symptoms (sore throat, cough, stuffy nose, sneezing); bruising or irritation where the medicine was injected. weakness. Together, you and your doctor can discuss the benefits and risks of treatment options for anemia. It depends. (A generic drug is an exact copy of the active drug in a brand-name medication.). Depending on your doctors instructions and This is not a complete list of side effects and others may occur. It will take about three weeks to feel the effects but your fatigue will disappear and you will feel like a new person. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Injectafer can be exposed to temperatures between 59F to 86F (15C to 30F) for a short period of time. Its responsible for carrying oxygen throughout your body. People from different ethnic backgrounds process medications differently. But call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. You should not be treated with this medicine if you have ever had an allergic reaction to an iron injection. Note: The Food and Drug Administration (FDA) tracks side effects of drugs they have approved. Effectiveness of Injectafer compared with iron thats taken by mouth. If youre not sure if youll need to get prior authorization for Injectafer, contact your insurance company. If you miss an appointment for your Injectafer dose, youll need to call your doctors office. Keep all regular medical and laboratory appointments. Injectafer is approved for use in adults who either: Injectafer contains the active drug ingredient ferric carboxymaltose. Those going through thismedical conditionshould speak to theircare teamfor support andguidance. Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Innovators Monograph In Canada - Call your doctor for medical advice about side effects. Heart failure: Could a low sodium diet sometimes do more harm than good? Some drugs may have another patient information leaflet. Follow your doctor's directions carefully. Before taking Injectafer, talk with your doctor about your health history. Some products that may interact with this drug include: vitamin products, other iron-containing products. If you have a severe allergic reaction to Injectafer after youve left the medical facility where you received your dose of the drug, call your doctor right away. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. You must check to make sure that it is safe for you to take Venofer with all of your drugs and health problems. With anemia, you have a low level of red blood cells (RBCs) in your body. Injectafer begins working as soon as it enters your body. Do not use Injectafer in people with a history of hypersensitivity reactions to Injectafer or any components of the drug product. If you have questions about the blood tests youll need to have done to monitor your anemia, talk with your doctor. Drug interactions: DayQuil can interact with other medications, including prescription drugs, over-the-counter medications, and herbal supplements. Data on file, American Regent, Inc. 1. You may report side effects to FDA at 1-800-FDA-1088. Iron infusion side effects vary depending on which form is being used. (For more information on Venofer, see the Injectafer vs. Venofer section above). If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Find out what health conditions may be a health risk when taken with Venofer Vial Your doctor will do laboratory tests to monitor your response. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Then your body uses that iron to make hemoglobin and RBCs. TheNational Instituteof Health (NIH) and the U.S.Food and Drug Administration(FDA) monitor the side effectsof new and approved medications to ensure safety. You will need to talk about the benefits and risks to you and the baby. Allergic reactions typically occur the first time your body is exposed to a drug. It may also cause nervousness, restlessness, and difficulty sleeping in some people. They can recommend appropriate treatment options. Low blood pressure. But the length of time that this may take varies from person to person. Theyll do this by checking certain blood tests. other treatments you receive, you will need to go back for several treatments with Venofer. 1 0 obj If youre wondering how longside effectslast, youll be happy to know they can last just a few hours. For more information about taking Injectafer during pregnancy, see the section Injectafer and pregnancy above. (See also Notes section.). This website is intended for use by US healthcare professionals only. If you think there has been an overdose, call your poison control center or get medical care right away. Side effectsare uncomfortable reactions to medications or drugs. And these two doses need to be separated by at least 7 days. And this can lead to anemia, including IDA. (One treatment course includes two doses of the drug.) Injectafer comes as a liquid solution inside vials. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. Together, they can recommend ways to help you manage a body weight thats healthy for you. Phosphorus is an electrolyte that your body needs in order to make energy. Its not known if Injectafer is safe to use during pregnancy. These pregnancy-related problems include preterm delivery and low birth weight of your infant. Brand-name medications usually cost more than generics. These lists contain up to 10 of the most common mild side effects that can occur with Injectafer, with Venofer, or with both drugs (when taken individually). <> VenAccess is a trademark of Vifor (International) Inc. Switzerland. Do not share your drugs with others and do not take anyone else's drugs. However, since peoples bodies react so differently to drugs, they often have to change their stance on certaindrugs. Constipation,dry mouth, headaches, upset stomach, and many othercommonside effectscan greatly affect peoples quality of life, though. Its caused by your body not having enough iron, which is needed to make hemoglobin. The study also didnt show if one treatment was worse than the other. Ask your doctor or healthcare provider if Venofer is the right choice for you. After 5 weeks of treatment: This study didnt determine if either drug was better than the other. Injectafer and Feraheme are both brand-name drugs. It can also cause skin irritation and redness. Hypophosphatemia risk appears to be substantially lower with other IV iron formulations. Injectafer isnt known to interact with any other medications, herbs, supplements, or foods. You would receive 15 mg of Injectafer per kilogram of body weight for each of your two doses. Iron is a vital mineral in the body, central to transporting oxygen around the body in the hemoglobin. Iron is important for many functions in the body, especially for the transport of oxygen in the blood. Injectafer helps to treat IDA by providing an iron infusion directly into your body. Learn how to store and discard medical supplies safely. Call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. These people may lose weight as their anemia improves because theyre more active. In the US - Call your doctor for medical advice about side effects. Generic name: iron sucrose (injection) [EYE-urn-SOO-krose] Knowing how longside effectslast can help with the decision on whether to use a particulardrug. But even if youre not at risk for the condition, your doctor may still monitor your phosphorus levels. muscle pain. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Theseside effectsmay last as long as they are undercancer treatment. However, diarrhea it isnt very common in people using Injectafer. There may be risks to the mother and fetus associated with untreated IDA in pregnancy. The following information describes dosages that are commonly used or recommended. Most of these side effects may go away within a few days or a couple of weeks. wAd**CgI%"nn{Oa[q{r5 Mental healthdisorders like depression may requireantidepressantsto treat. In this study, compared with their level before treatment: Injectafer isnt currently approved for use in children. Most people will metabolize medication by half every time it circulates the body. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. This site is intended for use only by US patients. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Venofer. Dr. Colby is alsothe Founder of Sequencing.com and the authorofOutsmart Your Genes. stream This allows them to manage any side effects that you may have following your dose. However, some people may have weight changes as they have improvement in their anemia, which Injectafer is used to treat. (A medication class describes a group of drugs that work in the same way.). Patients with iron-deficiency anemia who are having high blood loss surgery (> 500 ml) within the next 2 months and need to replace iron quickly. Call your healthcare provider or get medical help right away if you have symptoms of an allergic reaction, including but not limited to rash, chest pain, cough, dizziness, passing out, shortness of breath, sweating or throat tightness. However, since peoples bodies react so differently to drugs, they often have to change their stance on certain drugs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Venofer may cause significant hypotension (decreased blood pressure). With a delayed reaction, your body reacts to a drug that youve been exposed to in the past without having a reaction. Remember that it is best to get your vitamins and minerals from food whenever possible. Also, keep in mind that if your anemia is causing certain symptoms, treatment with Injectafer may help those symptoms go away. However, consuming large amounts of alcohol can actually cause anemia in some people. Instead, youll start by receiving just one treatment course of Injectafer. With CKD, your kidneys dont function properly, which can lead to your body having problems using iron. Injectafer and Venofer are both brand-name drugs. Patients should induce vomiting or evacuate the stomach by lavage during Venofer overdoasge. Side effects like nausea and low blood pressure are common with most iron infusions. Injectafer is approved to treat iron deficiency anemia (IDA) in certain adults with the condition. Some people may also experience skin irritation from the adhesive tape and other medical equipment used during the procedure. Things to remember when you fill your prescription. In fact, Injectafer is meant for some people whose anemia didnt improve with iron pills or for people who had side effects from iron pills. If you are allergic to Venofer; any part of this medicine; or any other drugs, foods, or substances. The researchers found that compared with their hemoglobin level before the study: But the actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. These drugs have been compared in a clinical trial of adults with both IDA and CKD who didnt need dialysis. If a person does not have an allergic response or any other unanticipated reactions, a doctor will administer the remaining iron. Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Hemoglobin is a protein thats found in your RBCs. Before taking Injectafer, be sure to tell your doctor or pharmacist about any medications you take, including any over-the-counter vitamins or supplements. Most people do not know how long theirside effectswill last until they go through them. WARNINGS/CAUTIONS: Serious hypersensitivity reactions, including anaphylactic-type reactions (itching, hives, swelling, wheezing, difficulty breathing, fainting and/or other allergy symptoms), some of which have been life threatening and fatal, have happened in patients receiving Venofer. The dosing for iron replacement treatment in pediatric patients less than 2 years old with Peritoneal or Hemodialysis-Dependent CKD or Non-Dialysis-Dependent CKD have not been established. Yes, in some cases it may. Symptoms of a severe allergic reaction can include: Because of the risk of allergic reaction with Injectafer, your healthcare professional will monitor you for at least 30 minutes after you get each dose of the drug. However, side effects at the 150 mg dose may indicate that you might not . Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. Headache. Depending on your anemia symptoms, your weight changes may be different than those described here. Orofer S 50 Injection 1 Injection in 1 Packet 147. A shortage of iron can cause health problems. This information is not specific medical advice and does not replace information you receive from the healthcare provider. 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Venofer (iron sucrose) can also be mixed in a saline solution and given through an IV over a longer time. In one study, people were given either Injectafer or an iron replacement drug called Venofer. And this can affect how well those parts of your body are able to work. And babies born to those who took Injectafer during pregnancy didnt have any major congenital anomalies (also sometimes called birth defects). Clinical trials showed that Injectafer is effective in increasing hemoglobin levels in people with iron deficiency anemia (IDA). Severeside effectscan lead to injury or death -drowsinesscan cause a car accident or injury when operating heavymachinery. In this group, after 35 days of treatment: In clinical studies, Injectafer was effective in treating IDA in adults with CKD who didnt require dialysis. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. You should not receive Venofer if you have known allergies to iron sucrose. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Theseside effectscan range from being mild tosevere. Many patients with kidney disease cannot get enough iron from food and require injections. But you likely wont feel the drug working inside of you. If you have questions about the best diet for you during Injectafer treatment, talk with your doctor. }|54U|O~?|_v;f\o^(W+/-|^)O65_)rd sm }[x[)y.z Wz?9_jV0ub,`g`s?oXOSp/Kgw$b!Vb$;IvBVR9n|\0ln=;/=,mgw@do,[";/8nJL{n}Bb-|^6[~>a_1H'^M:^vv=iM+x|+Y It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Common side effects may include: fever, cold or flu symptoms ( sore throat, cough, stuffy nose, sneezing); high or low blood pressure; headache, dizziness; nausea, vomiting; diarrhea; People who weigh less than 110 lb (about 50 kg) will receive two separate Injectafer doses of 15 mg/kg of body weight. As a result, you may not make as much EPO as usual. Cholesterolmedication may reduce the risk of a stroke but it can decrease the quality of life for some people but causingweight gain, dizziness, nausea, and musclepain. In pediatric patients the most common side effects (>2%) are headache, viral respiratory tract infection, peritonitis, upset stomach, throwing up, fever, dizziness, cough, arteriovenous fistula thrombosis, hypotension and hypertension (increased blood pressure). The Food and Drug Administration (FDA) approves prescription drugs such as Injectafer to treat certain conditions. Iron sucrose can also be mixed in a. Venofer injection contains iron sucrose, a form of the mineral iron. This treatment course is split into two doses of the drug, which are given at least 7 days apart. With this condition, you also have a low hemoglobin level. Examples of these side effects include dizziness and nausea. (Hemoglobin is a protein thats found in your red blood cells.). US residents can call their local poison control center at 1-800-222-1222. It is important to get each dose of this medication as scheduled. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Its not currently available in generic form. (A generic drug is an exact copy of the active drug in a brand-name medication.) Infusion times range from less than 20 minutes to up to 4 hours. Some people are simply allergic to an active ingredient in the medication, so the body responds undesirably. Tell your doctor about the allergy and what signs you had. cough. One of the most commonly used tests to monitor IDA is the hemoglobin test. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Can diet help improve depression symptoms? These effects typically last between 7 and 11 hours. If you have questions about side effects, call your doctor. This way, if you have an allergic reaction to Injectafer, your healthcare professional can treat your reaction. There may be drug take-back programs in your area. In clinical trials, serious allergic reactions occurred in 0.1% to 1.5% of people taking Injectafer. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Low iron saturation, or iron deficiency, has various possible causes. This may lead to the person needing a higher dose compared to someone who is muchsmaller. Injectafer contains the active drug ferric carboxymaltose, while Venofer contains the active drug iron sucrose. But call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. Procedure Details With IV infusion, the drug is given as a slow drip into your vein over a period of time. experience severe side effects, please seek medical attention right away and notify the ordering physician. Vomiting. Usually, when drugs may cause an immune system reaction like this, its a concern with your first dose of the drug. You may report side effects to Health Canada at 1-866-234-2345. You may report side effects to the FDA at 1-800-332-1088. Learn how to store and discard medical supplies safely. Its not known how often people taking a treatment other than Injectafer had diarrhea. Call your doctor for medical advice about side effects. Injectafer is available only as a brand-name medication. If you have questions about using Injectafer for anemia during pregnancy, talk with your doctor. Your doctor will monitor your hemoglobin level to tell if Injectafer is working for you. Patients with celiac disease (gluten intolerance). And this type of reaction is possible even if you didnt have a reaction to your first dose of the drug. A boxed warning is the most serious warning the Food and Drug Administration (FDA) can issue about a drug. Venofer also comes as a liquid thats given by either IV infusion or a slow IV injection. Since someallergic reactionscan belife-threatening, its essential to discuss any adverse events previously experienced with the prescribingphysician. Iron-refractory iron deficiency anemia (IRIDA) is a genetic form of anemia. It's a more immediate treatment than supplements or dietary changes. You will be watched closely by your doctor for 30 minutes after each dose. Drug class: Iron products. Use of the term female in this article refers to sex assigned at birth. For instance, someone with lowblood pressuremay receive a medication to prevent migraines that lowersblood pressure, this may causeseriousside effects. If you would like to report to the FDA a side effect youve had with Injectafer, you can do so through MedWatch. If you need to store Venofer at home, talk with your doctor, nurse, or pharmacist about how to store it. It belongs to a class of medications called iron replacement products. For some people, after receiving one treatment course (two doses) of Injectafer, their IDA is resolved. If you have any questions about Venofer, please talk with your doctor, nurse, pharmacist, or other health care provider. Generics tend to cost less than brand-name drugs. And if you dont have an allergic reaction to your first dose of a drug, its typically safe to assume you wont have an allergic reaction to doses that follow. Injectafer and Feraheme can cause very similar side effects, but some different ones as well. Last updated August 20, 2020. Side effectswill last a very long time if the cause of them is not resolved. monitor along with your hemoglobin and red blood cell count: The Venofer patient brochure provides information and support for CKD patients (2 years and older) with IDA. Then the study was split into the following two groups, which are discussed below. In severe cases, it can cause asthma-like symptoms, such as wheezing and difficulty breathing. Do not flush down a toilet or pour down a drain unless you are told to do so. With slow IV injection, the drug is given as a single, slow injection into your vein. 2 0 obj We comply with the HONcode standard for trustworthy health information. Tell your doctor if you are taking iron supplements or other iron-based oral medications, such as: This list is not complete. endobj These are not all of the side effects that may occur. But in some people, Injectafer can cause symptoms of hypophosphatemia to occur. No, you wont need to take iron pills while youre using Injectafer. It can be given as a slow injection over 2 to 5 minutes or as an infusion. Version: 7.01. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. You may report side effects to the FDA at 1-800-332-1088. This is not a complete list of possible side effects. Weight changes may be due to symptoms of anemia improving. The body cannot metabolize such a high dose fast enough, so it ends up affecting a part of the body it wasnt intended to, such as the stomach. Cardiovascular health: Insomnia linked to greater risk of heart attack. Together, you and your doctor can develop a treatment plan thats best for you. But for other people, their anemia may come back after Injectafer treatment. Iron sucrose injection has a molecular weight of approximately 34,000 - 60,000 daltons and a proposed structural formula: Youll receive doses of either drug by a healthcare professional at a medical facility. And this person had gotten their first dose of the drug without having an allergic reaction. %PDF-1.3 Their medical staff can help you set up another time to receive your Injectafer dose. Typical Injectafer doses for iron deficiency anemia (IDA) depends on your body weight. Venofer pregnancy and breastfeeding warnings. Learn more about the types of tests and treatment. "That's why it's so . If you come into contact with Red Tide, it can cause respiratory irritation, coughing, and sneezing. They can tell you about other medications that may work well for you. It is very important that your doctor check you closely while you are receiving this medicine. Any long-term side effects/dangers from iron infusions? Sharing this information can help you avoid potential interactions. 2023 Medicine.com All rights reserved. Excessive amounts of Venofer may lead to a condition called iron overload, which may be harmful. <> In this group, after 35 days of treatment: Effectiveness of Injectafer compared with a different IV iron product. A delayed reaction can occur in two different ways: It can happen hours or days after you receive a drug, or it can happen after a second (or later) dose of a drug. Side effects: DayQuil can cause side effects such as drowsiness, dizziness, nausea, vomiting, and stomach upset. How long it takes for the bodyto break down the meds matters and some peoples bodies simply take longer than others. However, many people have no side effects or only have minor side effects. Does Venofer Vial interact with other drugs you are taking? But so far I feel better than before the infusion. Someside effectsare temporary or last as long as the person continues takingprescription medicine. In this study, researchers compared Feraheme treatment with that of ferric carboxymaltose (the active drug in Injectafer). % Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. generalized weakness. So the goal of IDA treatment with Injectafer is to bring your hemoglobin level back to a value thats within normal range. Injectafer and Feraheme have different approved uses, but theyre both used to treat IDA in certain adults. Maximum concentrations of Injectafer are achieved within 15 minutes to 1.21 hours following administration. On the other hand, some people may have a poor appetite that goes away when their anemia is treated. Many people using this medication do not have serious side effects. If you have questions about side effects, call your doctor. You are encouraged to report side effects to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. However, to be safe, tell your doctor or pharmacist about all prescription, over-the-counter, and other drugs you take before taking Injectafer. An iron infusion is a way to increase the body's iron levels quickly. (IV iron is absorbed by the body more rapidly than oral iron.) Your healthcare provider will watch you closely for 30 minutes after each dose. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. So you wont pick up this medication from a pharmacy. Pain, swelling, or redness at the injection site may occur. No, Injectafer itself wont make you gain weight. With IV infusion, the drug is given as a slow drip into your vein over a period of time. Nose or throat irritation. Only 10 mg may be excreted by the body the next time it goes through the liver, and possibly only 5 mg the nextpass. These include: Note: For more information about the potential negative effects of Injectafer, see the Injectafer side effects section above. Venofer (iron sucrose injection, USP) Rx Only DESCRIPTION Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)-hydroxide in sucrose for intravenous use.

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